helix
corner helix border
helix background and resume current and past projects comments from class participants frequent asked questions about DNA related links of interest border
helix border
helix
helix border
Molecular Translations, Inc. services offered contact for further information return to homepage border
border
border

background

I am a Molecular Biologist trained at Harvard Medical School, the University of Oxford, and Boston University. My research has involved biochemical analysis, protein-protein interaction, gene cloning, DNA sequencing, and polymerase chain reaction (PCR) technologies in the areas of microbiology, drug resistance, immunology, and hematology. As an editor, writer, course developer, and teacher of university students and the general public, I have refined the art of making the seemingly incomprehensible comprehensible. Molecular Translations, Inc. has grown out of my belief that the life sciences and biomedicine are both important and understandable to everyone. It is the mission of Molecular Translations, Inc. to help its clients make sense out of science.

Gail S. Begley, Ph.D.
President, Molecular Translations, Inc.

 anthrax molecule Anthrax Toxin Lethal Factor, Protein Data Bank, A. D. Pannifer, et. al, Nature, 2001.

curriculum vitae

Education

Postdoctoral, Harvard University School of Medicine 1997-1999
Postdoctoral, Oxford University, Institute of Molecular Medicine 1995-1997
Ph.D., Cell and Molecular Biology, 1995, Boston University
M.A., Biology, 1983, Boston University
B.S., Biology, Summa Cum Laude, 1980, Suffolk University

Honors & Awards

National Bioterrorism Plan Presentation, AAAS, Washington, DC
National Public Health Service Postdoctoral Training Award in Medicine: Hematology
Imperial Cancer Research Fund Postdoctoral Research Fellowship
National Public Health Service Predoctoral Training Award in Molecular Biophysics
Sigma Xi Research Grant
Boston University Research Assistantship
Boston University Teaching Fellowship
Suffolk University Trustees Graduate Scholarship
Suffolk University Biology Department Award
Suffolk University Modern Languages Department Award (German)

Memberships

American Society for Biochemistry and Molecular Biology (ASBMB)
American Association for the Advancement of Science
American Society for Microbiology

Current Faculty Appointment

Department of Biology
Northeastern University
Boston, Massachusetts

Teaching Experience

Training/Short Courses:

  • Bioterrorism in the Mail
  • The Microbial Battlefield
  • Genes Are US
  • The Art of Science Communication
  • Coastal Pollution Issues

College Courses:

  • Molecular Biology
  • Microbiology
  • Biochemistry
  • Research
  • Science and Technology Today
  • General Biology
  • Membrane Transport
  • Genetics
  • Cell Biology

Editing & Writing Experience

  • Editing manuscripts of non-native speakers for publication in English language journals
  • Editing reports to Congress and the Environmental Protection Agency
  • Editing technical reports
  • Editing license support documents
  • Writing critical reviews (Science Books & Films)
  • Reviewing literature and selecting manuscripts
    (Associate Editor of Oceanographic Literature Review)
  • Writing abstracts
  • Writing and editing laboratory manuals
  • Writing original research articles for peer-reviewed journal publication

Summary of Research Experience

I have cloned, sequenced, and characterized genes important in blood clotting, neurotoxicity, multidrug resistance, cancer, cystic fibrosis, immune response, and microbial physiology using a variety of techniques, especially the polymerase chain reaction (PCR) and molecular cloning technologies.

Selected Publications

Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F.  2005.  Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.  Mol Immunol. 42(1):137-41. 

Brown MA*, Begley GS*, Czerwiec E, Stenberg LM, Jacobs M, Kalume DE, Roepstorff P, Stenflo J, Furie BC, Furie B. 2005. Precursors of Novel Gla-Containing Conotoxins Contain a Carboxy-Terminal Recognition Site That Directs gamma-Carboxylation. Biochemistry, 44(25):9150-9159.  (* co-lead authors)

Jessen-Eller, K., J.A. Kreiling, G S. Begley, M.E. Steele, C.W. Walker, R.E. Stephens, and C.L. Reinisch. 2002. A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls. Environ Health Perspect. 110(4):377-85.

Taylor, J.C., A.R. Horvath, C.F. Higgins, and G.S. Begley. 2001. The multidrug resistance p-glycoprotein: oligomeric state and intramolecular interactions. J. Biol. Chem. 276 (39):36075-8.

Begley, G.S., B.C. Furie, E. Czerwiec, K.L.Taylor, G.L. Furie, L. Bronstein, J. Stenflo, and B. Furie. 2000. A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla. J. Biol. Chem. 275 (46): 36245-36249.

Begley, G.D., K. Warner, J.C. Arents, P.W. Postma, and G.R. Jacobson.  1996.  Isolation and characterization of a mutation that alters substrate specificity of the Escherichia coli glucose permease. J. Bacteriol. 178(3):940-2.

Begley, G.S., and G.R. Jacobson.  1994.  Overexpression, phosphorylation and growth effects of ORF162, a Klebsiella pneumoniae protein that is encoded by a gene linked to rpoN, the gene encoding sigma-54. FEMS Microbiol. Lett. 119(3):389-94.


  
border
spacer spacer spacer spacer spacer spacer spacer spacer spacer spacer